Sunday, June 30, 2013

Effects of a Pomegranate Fruit Extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis

Atherosclerosis is enhanced in arterial segments exposed to disturbed flow. Perturbed shear stress increases the expression of oxidation-sensitive responsive genes (such as ELK-1 and p-CREB). Polyphenolic antioxidants contained in the juice derived from the pomegranate contribute to the reduction of oxidative stress and atherogenesis during disturbed shear stress.
Aim of the study: To evaluate the effects of intervention with the Pomegranate Fruit Extract (PFE) rich in polyphones (punicalagin, which is a potent antioxidant) on ELK-1, p-CREB, and endothelial nitric oxide synthase (eNOS) expression induced by high shear stress in vitro and in vivo.
Results: At the doses used in the study, both the PFE and the regular pomegranate juice concentrate reduced the activation of ELK-1 and p-CREB and increased eNOS expression (which was decreased by perturbed shear stress) in cultured human endothelial cells and in atherosclerosis-prone areas of hypercholesterolemic mice. PFE and pomegranate juice increased cyclic GMP levels while there was no significant effect of both compounds on the conversion of L-arginine to L-citrulline. Administration of these compounds to hypercholesterolemic mice significantly reduced the progression of atherosclerosis and isoprostane levels and increased nitrates. This protective effect was relevant with PFE. Vasomotor reactivity was improved and EC25 values in response to Ach and NONOate were significantly increased in treated mice in comparison to controls.
Conclusion: This study indicates that the proatherogenic effects induced by perturbed shear stress can be also reversed by chronic administration of PFE.

Pomegranate: How To Clean Your Arteries With One Simple Fruit

The future of cardiovascular disease prevention and treatment will not be found in your medicine cabinet, rather in your kitchen cupboard or in your back yard growing on a tree.
Pomegranate Found To Prevent Coronary Artery Disease Progression
A new study published in the journal Atherosclerosis confirms that pomegranate extract may prevent and/or reverse the primary pathology associated with cardiac mortality: the progressive thickening of the coronary arteries caused by the accumulation of fatty materials known as atherosclerosis.[i]
Mice with a genetic susceptibility towards spontaneous coronary artery blockages were given pomegranate extract via their drinking water for two weeks, beginning at three weeks of age. Despite the fact that pomegranate treatment actually increased cholesterol levels associated with very low density lipoprotein-sized particles, the treatment both reduced the size of the atherosclerotic plaques in the aortic sinus (the dilated opening above the aortic valve) and reduced the proportion of coronary arteries with occlusive atherosclerotic plaques.
Remarkably, the researchers also found that pomegranate extract treatment resulted in the following beneficial effects:
  • Reduced levels of oxidative stress
  • Reduced monocytie chemotactic protein-1, a chemical messenger (chemokine) associated with inflammatory processes within the arteries.  
  • Reduced lipid accumulation in the heart muscle
  • Reduced macrophage infiltration in the heart muscle
  • Reduced levels of monocyte chemotactic protein-1 and fibrosis in the myocardium
  • Reduced cardiac enlargement
  • Reduced ECG abnormalities
How can something as benign and commonplace as a fruit extract reverse so many aspects of coronary artery disease, simultaneously, as evidenced by the study above?  The answer may lie in the fact that our ancestors co-evolved with certain foods (fruits in particular) for so long that a lack of adequate quantities of these foods may directly result in deteriorating organ function.  Indeed, two-time Nobel Prize winner Linus Pauling argued that vitamin C deficiency is a fundamental cause of cardiovascular disease, owing to the fact that our hominid primate ancestors once had year-round access to fruits, and as a result lost the ability to synthesize it. 

Discussion

This study adds to the already extant body of clinical research indicating that pomegranate can help unclog your arteries.  For instance, back in 2004, the journal Clinical Nutrition published the results of a three year clinical trial in an Israeli population, finding that the daily consumption of pomegranate juice reversed carotid artery stenosis by up to 29% within 1 year.  Remarkably, the blockages in the control group increased 9%, indicating that pomegranate's artery unblocking effects were even greater than at first apparent. [ii]
Pomegranate's value in cardiovascular disease is quite broad, as evidenced by the following experimentally confirmed properties:
  • Anti-inflammatory: Like many chronic degenerative diseases, inflammation plays a significant role in cardiovascular disease pathogenesis. There are five studies on GreenMedInfo.com indicating pomegranate's anti-inflammatory properties.[iii]
  • Blood-Pressure Lowering: Pomegranate juice has natural angiotensin converting enzyme inhibiting properties, [iv] and is a nitric oxide enhancer, two well-known pathways for reducing blood pressure. [v] Finally, pomegranate extract rich in punicalagin has been found reduce the adverse effects of perturbed stress on arterial segments exposed to disturbed flow.[vi]
  • Anti-Infective: Plaque buildup in the arteries often involves secondary viral and bacterial infection, including hepatitis C and Chlamydia pneumoniae.[vii] Pomegranate has a broad range of anti-bacterial and anti-viral properties.
  • Antioxidant: One of the ways in which blood lipids become heart disease-promoting (atherogenic) is through oxidation. LDL, for instance, may be technically 'elevated' but harmless as long as it does not readily oxidize. Pomegranate has been found to reduce the oxidative stress in the blood, as measured by serum paraoxonase levels.  One study in mice found this decrease in oxidative stress was associated with 44% reduction in the size of atherosclerotic lesions. [viii]
For additional research on pomegranate's heart friendly properties read our article: Research: Pomegranate May Reverse Blocked Arteries
Also, view our dedicated research section on reversing arterial plaque: Clogged Arteries

Resources


Friday, June 28, 2013

Extracts from Fresh Echinacea purpurea Material

Extracts from Fresh Plant Material

The majority of herbs are used in their dried form. There are those, however, which must be used in their fresh form to be useful as medicinals, since they lose their healing properties when dried. One herb of common usage (if we are to judge by retail sales of the extract) is Echinacea. Since this is easy to grow in the home garden and simple to make in the kitchen, this one will serve as the best example.
Echinacea purpurea is the one most commonly employed for medicinal purposes, but Native Americans had a number of different usages for the several varieties which were found in abundance. Both E. angustifolia and E. pallida can be used in place of E. purpurea for the purpose of boosting the immune system.

In fact, E. angustifolia was once the variety of choice for a wide range of ailments thought to require 'blood cleansing' and formed the basis for many of the 'snake-oil' nostrums of another era.

The difficulty in using fresh plant material is knowing what the ratio should be for each particular herb. It requires access to some very expensive tomes of scholarly work on the subject.

On the other hand, simply browsing the extract shelves of your local health food or herb store will give you valuable information. The ratio should be written clearly on the label. Be sure it is a standard extract and not one of those which purport to be 'super' strength or made by some process other than the familiar water/alcohol extraction method.

On the whole it is far safer to avoid experimenting with fresh extracts, other than the echinacea, unless you pursue some very serious study on the matter.

As wholesome as herbs seem, please remember that allergies to some herbs are common. Echinacea belongs to the same family as ragweed (Compositae - daisy family) and some people can be allergic to other members of this same family.

Although I am using specific amounts as a guide to make a reasonable amount of extract, it is not necessary to think in these amounts when doing this for yourself. This particular extract will be made in a 1 to 3 ratio (1 part herb to 3 parts liquid).

Sounds pretty straight forward until we remember that part of our liquid is already locked up in the plant material.

Uh oh - now what?
How do I separate the liquid weight from the dry weight?

(If you feel your anxiety level rising - screaming is permitted)

If you have a microwave or an oven - you can stop screaming. The process isn't that bad, but you might want to get out a calculator to help you with those mummified math skills you thought you'd never need after high school graduation.

We want 2 oz. of freshly dug, washed and patted dry Echinaea root (allow as much moisture as possible to dry from the root before weighing and processing). We also want another 1 or 2 oz. of root to test for water content.

Echinacea root should be harvested in its second year after one or two hard frosts.
Weigh your sample piece for testing.

Let us use 2 oz. as an example.

Coarsely chop the plant material and place on paper towels in the microwave and begin to slowly dry out the root at 50% power until it is quite dry. Or you can do the test several days in advance, get your results and go back and harvest more root for the extract.

Other methods of drying (but requiring more time) are to slowly dry the coarsely chopped material in a low-heat oven or on a dehydrator tray.

When the plant material is dry, weigh it again.
What is the weight now?

Deduct it from the original fresh weight and figure the percentage.

For the sake of argument, let us say that we began with 2 oz. of fresh root and now have 1 oz. of dry root - that would mean the plant contained 50% water or 1 oz. of liquid. This is the information we need to proceed. We will be making 6 oz. of extract with 2 oz. being equal to 1 'part' of the 3 parts of liquid.


Procedure
Step 1: 
Coarsely chop the root and place in a blender. We have 2 oz. of root which we know to be 50% water after drying our sample.

Since we are using a 50/50 water-alcohol medium to extract the plant properties and we know that we already have 1 oz. of water in the plant material, it merely remains to add enough pure alcohol (and *water if necessary) to make up the first 'part' of our formula. The closest we can get to pure alcohol is 190 proof (Please! no open flames or heated surfaces around this stuff! Extremely flammable).

(*If our plant material had been 40% water, we would add 1 oz. of alcohol plus a small amount of distilled water to make up the 10% difference.)

There are two products which can be purchased at this strenth - Everclear and Clear Spring.
Step 2: 
The water portion of the plant material is now accounted for in Step 1 and all that remains is to add the remaining 2 parts of liquid which is 50% water and 50% alcohol. Pour 4 oz. of 100 proof vodka (remember that this is 50% alcohol and 50% water) into the blender.

You now have root, pure alcohol, and the vodka in the blender. Of the liquid portion - 3 oz. is alcohol and 3 oz is water. There is 6 oz. of liquid to 2 oz of fresh root (part of which is water and accounted for). This makes a 1 to 3 ratio.

Step 3
Run the blender until the plant material is as fine as it is going to get and everything is well mixed. Pour the contents from the blender into a wide-mouth jar. Cap, label, and date the jar.

Allow this to steep in a warm spot out of direct light for a period of 2 weeks, remembering to shake the jar each day.

Step 4: 
After 2 weeks, strain the liquid from the solids through muslin or fine cheesecloth and extract as much of the liquid as you can. Strain the liquid again through a paper coffee filter.

Store the liquid extract in an amber dropper bottle and clearly label the bottle in this way:

"Echinacea
1:3 ratio
dosage = 5 to 15 drops daily when needed"
Okay - I used nice round numbers and your mental gears are still working around that little conundrum of "how much water is 10% of the whole needed?" that I managed to sneak past you in Step 1. I don't do 'brain-strain' well, but I can come pretty close to the exact amount by using the following chart and so will you.

1 oz = 2 Tbsp = 600 drops
1/2 oz = 1 Tbsp = 300 drops
1/4 oz = 1/2 Tbsp = 150 drops 
1 tsp = 100 drops 
1/2 tsp = 50 drops
1/4 tsp = 25 drops

So what is 10% of 1 oz?

It's the same as 10% of 600 drops - which is?

Bingo! You got it! 60 drops of distilled water.

Amazingly simple stuff and you can pat yourself on the back now. Always remember that 600 drops equals 1 oz. and that 100 drops equals 1 tsp. The rest will be easy to figure from there.

Now that your breathing easier, we can get into heart attack territory.
What if your plant material is 60% or even 70% water? After all - plants are rarely so obliging as to be 50% water. I should really end my discussion at this point ...... I'm thinking about it ........ nah - I'd be bombarded with email!!!

The total liquid is supposed to be 6 oz.

If your plant material is 75% water, then you already have 1½ oz of water locked up inside it.

Since a 50/50 liquid solution totaling 6 oz. is 3 oz. of water and 3 oz. of alcohol, it merely remains to add the other 1½ oz. of water to make up the complete total required.

Then you add the 3 oz. of pure alcohol and your liquid measurements are complete. These are placed in the blender and completed as above.

**Sterile (boiled) water is ALWAYS used in preparing products for home use**


HAVING SAID ALL OF THE ABOVE, I have offered it in the interest of serious herbal pursuit. For most home use, simply combining 2 oz. of fresh root with 6 oz. of 100 proof vodka, blending and following the above procedure for 2 weeks of steeping is all that is need to produce a working product. Simply allow an extra drop or two in the dosage to account for a slightly watered down version.

If the use of alcohol is not appealing to you, it is also possible to use 1 part herb to 5 parts vinegar in the same manner to extract the plant properties. It will not be as potent a blend though, since alcohol is required to extract certain plant compounds.

Extracts from Dried Plant Material

Extracts made from dried plant material comprise most of the herbal extract types. The standard ratio used when making a dry herb extract, also known as a tincture, is:
1 part dried herb to 8 parts liquid.
This is written as 1:8

Locating this ratio number on a purchased extract will tell you its strength.

Essentially, making a dried herbal extract involves the same procedure. You powder the herbs in a blender or coffee mill and then combine them with 8 times (in weight) as much liquid. For home purposes 100-proof vodka provides the ideal extracting medium since it is 50% water and 50% alcohol.


Extracts enable you to move the healing properties of an herb into a long-lasting medium of liquid. Shelf life of extracts is several years as compared to the dry herb in whole leaf or large chunk root form which are only viable for about one year. Dosage is also easier to judge with the liquid in a dropper bottle.
Amber tincture bottles are available from herbalware suppliers.

Let's work through one example to guide you along...
Weigh out 1/2 oz. of Dandelion leaf or root

If you are seriously interested in herbal preparations made at home, you will need a reliable kitchen scale!

Grind the herb to a powder in a coffee mill and place in a suitably large sealable jar. Cover the herb with 4 oz (this is 8 times as much liquid as herb) of 100-proof vodka. Cap and shake well to get the herb saturated throughout the liquid.

Place your jar in a warm spot out of direct light for a period of two weeks.
You will need to shake the jar each day.

At the end of two weeks you will strain the liquid through a coffee filter and bottle in sterile amber dropper bottles.

Label the bottle this way:

Dandelion extract - 1:8 ratio 
and add the date.  mm/yyyy

By the way - any cheap 100-proof vodka will do the job. It's not necessary to spend a great deal of money on a known brand.

Any herb which is used in its dry form can be made into an extract in this manner.

There are a few herbs which CANNOT be used dry since they lose their healing properties upon drying. For this reason they are used fresh.

Eight Benefits of Echinacea Tea

Echinacea tea is used as a traditional herbal treatment for relieving ailments from immune system problems. The herbal tea has a history of being used for hundreds of years by American Indians to fight colds, flus and infections. The echinacea plant itself from which the tea is derived can grow up to two or three feet in height and the flowers that bloom from it can be anywhere from a whitish rose color to a soft purple hue. There are many benefits that can be found from the use of this herbal tea. It has shown many favorable medical effects as well.

The Benefits of Drinking Echinacea Tea

  • The possibility that it could have antitumor properties has been studied, and though no conclusive evidence has been found regarding the matter it is thought to be true.
  • Studies have shown that drinking the herb can shorten the span of time that it normally takes to recover from the common cold. Testing proved that it can shorten recovery time by an average of 1.4 days.
  • As well as colds, echinacea tea has been reported to help enhance immunity against coughs and flus as well as other upper respiratory ailments. It stimulates your immune system and activates T-cell renewal.
  • The herb can be used to lower swollen or enlarged glands and help soothe a sore throat when ingested.
  • Urinary tract infections and other minor infections can be relieved by drinking this formula.
  • There is the possibility that if taken properly, echinacea tea can be used with other treatments to combat herpes and candida. The herb has been known to help white blood cells fight disease and germs, causing the effects of certain ailments to lower in intensity.
  • Echinacea herbal tea can also be used as a topical treatment, and has been found to aid in the healing of skin problems as well. This can include anything from ance, eczema, inflammations and irritations to sometimes painful boils.
  • Drinking echinacea tea has also been shown to help assist in healing of joint disorders as well as muscle problems.

An Echinacea Disclaimer

Though this herb has been known to have many health benefits and can provide a much needed boost to most people, there are times when taking this herb is not recommended. People with immune system diseases, such as HIV or AIDS, tuberculosis or multiple sclerosis, should not take any form of echinacea without consulting a physician first. Some research has shown that if taken, echinacea can actually irritate these kinds of diseases, making the symptoms and outbreaks worse than before taking the herb.
Though there are a few potentially negative side effects to echinacea tea usage, the positive side effects may surpass the deficiencies. Always ask your doctor before you drastically change your diet in any way, such as adding this herbal tea to your daily menu. Echineacea teas can be found at a variety of places, including health food stores and grocery stores.

Echinacea: Growing, Harvesting and Using

In the Midwest we call Echinacea purpurea, the coneflower and it can grow anywhere, where it is unkempt.
Promoters of Echinacea say that the herb encourages the immune system and reduces many of the symptoms of colds, flu and some other illnesses, infections and conditions. 

Echinacea has a complex mix of active substances, some of which are said to be antimicrobial, while others are believed to possibly have an effect on the human immune system.

All species of this herbal remedy have compounds called phenols. Many plants contain phenols, active substances which control the activity of a range of enzymes and cell receptors, and protect the plant from infections and UV radiation damage. Phenols have high antioxidant properties, which are good for human health.

Echinacea also contains alkylamides or alkamides, (not in E. pallida), which have an effect on the immune system.

Echinacea also contains polysaccharides, glycoproteins, and caffeic acid derivatives.
Studies have produced conflicting results as to the benefits of echinacea. Echinacea is used by people today for: Acid indigestion, Attention deficit-hyperactivity disorder (ADHD), Chronic fatigue syndrome, Diphtheria,
Dizziness, Genital herpes, Gum disease, Malaria, Migraines, Pain, Rattlesnake bites, Rheumatism, Septicemia - Bloodstream infections, Streptococcus infections, Syphilis, Flu, Tonsillitis, Typhoid, Urinary tract infections, Vaginal yeast infections.

Lovely in the garden and useful for treating common ailments, Coneflowers (Echinacea purpurea) are one plant your herb garden shouldn't be without. They belong to the plant family of Asteraceae which includes all of the thousands of species of asters, daisies, and sunflowers. Even with all of these relatives, Echinacea has a prominent place as an herb that is commonly grown in home herb gardens for beauty as well as usefulness.


Extensive testing has been done in Europe, especially Germany, where Echinacea is used to enhance the immune system and as a boost for fighting infection. It is also used elevate mood. Although there has been some controversy in the US medical community over whether the Echinacea claims are legitimate, those who have experienced the results do not doubt.
Echinacea is easy to grow. It prefers full sun, but will tolerate light shade. Rich soil will produce plants that are quite large, as tall as 5 feet or so, but it also grows well in less fertile soil. Plants are sensitive to too much water, and they should be planted where there is good drainage and little chance of puddling around the roots. An easy way to grow Echinacea is to give it an area of the garden and just allow it to reseed and grow as wildflowers. If you plant from seeds, you can plant them very early, about the same time you plant peas.
All parts of the plant are useful. The top growth should be harvested just before the flower buds open by cutting the stems just above the first or second pair of full green leaves. (It is normal to have a few dead leaves at the base of the plant.) Make a good, clean cut and new growth will emerge for another harvest. Kitchen shears are a handy way to just snip off the top growth. Wash the herb by gathering a small handful of stems and swishing them gently in water. Then tie them into bundles and hang them up to dry, or spread them out on a screen to dry. As with all herbs, keep them out of direct sunlight and leave plenty of room for air circulation. The leaves will crumble easily when they are completely dry. A dehydrator may also be used for quicker drying or in humid climates; use the lowest heat setting.
Roots should be harvested in the fall when the top growth has been killed by hard frost. If there are seed heads on the plants, distribute them on the ground if you want additional plants the next year. Harvest roots from well-established plants. Removing root growth from plants younger than 3-4 years may result in killing the plant. To harvest Echinacea roots, lift the plant and tip it back using a garden fork. Use a very sharp knife and clean-cut the portions of root that you want to harvest. Be sure to leave enough root to sustain the plant. A good rule of thumb is to harvest about 20% of root if you intend to make annual harvests. Replace the plant, firm the soil around the disturbed roots, and replace the mulch for the winter.
Prepare Echinacea roots by washing them completely. Cut them into pieces about 1/2 inch or so in size to shorten drying time. Smaller pieces are also not as likely to mold during drying. Hang the pieces in netting or cheesecloth bags to dry, or spread them out on a screen. A dehydrator will dry roots with a minimum risk of mold; always use the lowest heat setting and check the dehydrator often.
To make a light and flavorful tea from the dried flowers and leaves, use 2 teaspoons of dried herb and one cup of boiling water. Steep for 15 minutes and strain the tea. Add honey or lemon as desired.
Roots are used to brew a decoction, which is a stronger tasting liquid that is more potent. To brew a decoction, use 2 teaspoons of dried root with one cup of water and simmer them together in a tightly covered pot on very low heat for 30 - 60 minutes. The simmer time can be reduced if the root is ground or chopped into smaller pieces. (Be sure to use a tight-fitting lid so the water won't boil away.) Strain the liquid and it's ready to drink; add honey or lemon to taste. This stronger version is recommended as a dose for treating a cold or infection.
  • The traditional Echinacea angustifolia was used extensively by Native Americans. This variety grows to 5 feet tall and 5 feet wide, and is covered with smaller 2 inch pink or purple blossoms.
    Mainly the root of this plant is used medicinally.

Sources:
Personal experience and love of gardening
http://www.gardenguides.com/how-to/tipstechniques/herbs/coneflower.asp

Thursday, June 27, 2013

Peanuts cut Type 2 diabetes risk, hunger

They're inexpensive, they're childhood lunchbox staples, and now a new study indicates that peanut butter and peanuts, when eaten for breakfast, can curb hunger and control blood sugar levels throughout the day.
The small study, published this month in the British Journal of Nutrition, involved 15 obese women with high risk of developing Type 2 diabetes. The findings, researchers say, are promising because peanuts and peanut butter may help overweight people control their appetites. And the foods, which are already common worldwide, aid in keeping blood sugars stable - something that's important to a population at risk for Type 2 diabetes.
The scientists tested the dietary effects of peanuts and peanut butter in three phases. In one phase, the women ate 1.5 ounces of peanuts for breakfast, along with orange juice and Cream of Wheat cereal. In another phase, the same women substituted 3 tablespoons of peanut butter for the peanuts. The third, the "control phase," was given just the juice and cereal.
When the women ate peanuts or peanut butter, they reported a lower-than-usual desire to eat for up to 12 hours after breakfast. The women's blood samples revealed that when they ate peanuts and peanut butter, their production of an appetite-suppressing hormone called peptide YY increased.
Blood sugar levels, which naturally rise as the body digests food after meals, did not rise as much after breakfasts that included peanuts and peanut butter. And although the women didn't eat peanut products at lunch, their blood sugar levels didn't rise as much as usual after that midday meal.
Peanut butter yielded slightly better results than whole peanuts. But, in both cases, researchers credit peanuts' high levels of protein and healthy fats for their ability to stave off hunger. Peanuts have about 8 grams of protein per ounce - the highest of any nut.

Military Pokes Holes In Acupuncture Skeptics' Theory

In a fluorescent-lit exam room, Col. Rochelle Wasserman sticks ballpoint-size pins in the ears of Sgt. Rick Remalia.
Remalia broke his back, hip and pelvis during a rollover caused by a pair of rocket-propelled grenades in Afghanistan. He still walks with a cane and suffers from mild traumatic brain injury. Pain is an everyday occurrence, which is where the needles come in.
"I've had a lot of treatment, and this is the first treatment that I've had where I've been like, OK, wow, I've actually seen a really big difference," he says.
'Let's Give It A Shot'
Army doctors have been told by the top brass to rethink their "pill for every ill" approach to treating pain. For the 47,000 troops who've been wounded in Iraq and Afghanistan, some of the new options include less tried and true methods, like massage and chiropractic treatments. The military hopes to win over skeptics, many of them in uniform.
Wasserman is the top doctor for the Warrior Transition Battalion at Fort Campbell, Ky. To her own surprise, she's also now the unit's physician trained to do acupuncture.
"I actually had a demonstration of acupuncture on me, and I'm not a spring chicken," she says, "and it didn't make me 16 again, but it certainly did make me feel better than I had, so I figured, hey ... let's give it a shot with our soldiers here."
In recent years, military doctors have turned to acupuncture in special pain clinics and for troops in battle zones. Last year, the Army surgeon general began making the alternative treatments more widely available.
Steering Away From Painkillers
Remalia says his headaches have disappeared, and he's relying less on his cabinet full of pain medication. To Col. Kevin Galloway, that's mission accomplished. He's in charge of carrying out recommendations from the Army's Pain Management Task Force, which focused heavily on unconventional therapies.
"You can throw fairly cheap pharmaceuticals at the problem now and push the problem to someone else later if you're not really working on what the genesis of the pain is," he says.
Galloway says if soldiers get hooked on high-powered painkillers, the Department of Veterans Affairs may be dealing with the side effects for decades to come. Already, at least 40 percent of veterans entering the VA system are coping with pain.
'Quack-Ademic' Medicine
New academic studies from places like Duke University back up acupuncture as an alternative to medication.
But Harriet Hall, a former Air Force flight surgeon, shares the skepticism found in many corners of the medical community.
"We call that 'quack-ademic' medicine when it gets into medical schools," she says.
The way she reads the science, acupuncture does no more than a sugar pill. To offer a placebo, she says, is unethical.
"The military has led the way on trauma care and things like that, but the idea that putting needles in somebody's ear is going to substitute for things like morphine is just ridiculous," Hall says.
A Chance At Normalcy
As some top medical officers put it, though, there's nothing like pain to make someone open-minded. Staff Sgt. Jermaine Louis says he's tried it all.
"Physical therapy, occupational therapy, PTSD group, anger group, stress group ... everything," he says.
Louis is trying to overcome a traumatic brain injury that followed him home from Iraq five years ago. He's still dependent on medication, and the soon-to-retire infantryman says he's scared.
"[Scared] that I have to be on it for the rest of my life and [that] I will get accustomed just to taking them, and I don't want to be that way," Louis says. "I want to be normal like everybody else."
But if being normal depends on regular acupuncture treatments, the Defense Department has more convincing to do. TRICARE — the military's own health plan for service members and retirees — still doesn't cover acupuncture.

Aspartame Damages The Brain at Any Dose

Did you know that Aspartame has been proven to cause brain damage by leaving traces of Methanol in the blood? It makes you wonder why Aspartame has been approved as “safe” and is found in thousands of food products. Currently more than 90 countries have given the artificial sweetener the “OK” to be used in foods.
“Multiple Sclerosis is often misdiagnosed, and that it could be aspartame poisoning” 
Given that Aspartame is 200 times sweeter than sugar, manufacturers are able to produce their sweet foods and market them as “low calorie” so they can market and appeal to millions of people on “diets.” There is no doubt that the less sugar you have in your diet, the better. But replacing sugar with aspartame is not the solution, and in fact is likely to be even worse for your health.
In my personal experience, Aspartame has always made my head feel very odd when I consumed it. Headaches, light headedness and overall nausea, are all symptoms I personally feel from consuming Aspartame. But that isn’t even the bad part when you look at what all of the research is suggesting. So I question, and everyone should be asking the same: With all of the research about Aspartame and its dangerous effects, even in small quantities, why is it still approved by the FDA and other health agencies as being safe for human consumption? There are better solutions available and with less danger and side effects.

What is this lovely substance (Aspartame) made of?

An Aspartame molecule is essentially made up of 3 different substances. 90% of it is made of two natural amino acids, 1 being aspartic acid and the other being phenylalanine. The other 10% of the molecule is made up of a methyl ester bond (includes Methanol). The methanol is released from the aspartame within hours of consumption and begins traveling through the body via the blood. Once the methyl ester bond is broken, it liberates methyl alcohol or methanol (wood alcohol). The big problem with methanol is that it easily passes into your blood-brain barrier and once there, is converted into formaldehyde. Formaldehyde is what is causing the brain damage. While animals are able to detoxify methanol in the body, humans do not have this capability. It doesn’t really take a rocket scientist to realize that accumulating formaldehyde in the brain is not a good thing.

What’s the deal with Methanol?

As mentioned above, Methanol is the key issue here as it is what converts into formaldehyde. While it is often believed that formic acid is the issue with Aspartame, it is actually formaldehyde. Formaldehyde is a serious neurotoxin and carcinogen. According to the EPA, Methanol is considered a cumulative poison which means is accumulates in the body and very little is excreted each time it is consumed.
Methanol is a toxin that destroys the myelin tissue in your body, which is the insulating material around your nerves that allows nerve signals to travel properly. Once injured, one can have what are called demyelinating symptoms that are commonly seen in diseases like MS and also migraines that can include bizarre and inconsistent visual field disruptions.

But it must be safe in small doses!

While having NO methanol in the body makes most sense, the EPA has accepted that a limit of consumption of 7.8 mg/day is still OK. Why we accept even small amounts of toxic stuff in our body is beyond me, but some feel we can still consume this stuff in small doses. According to Woodrow Monte, Ph.D, R.D., director of the Food Science and Nutrition Laboratory at Arizona State University:
“When diet sodas and soft drinks, sweetened with aspartame, are used to replace fluid loss during exercise and physical exertion in hot climates, the intake of methanol can exceed 250 mg/day or 32 times the Environmental Protection Agency’s recommended limit of consumption for this cumulative toxin.”
Further, he states that due to the lack of a couple of key enzymes, humans are many times more sensitive to the toxic effects of methanol than animals. Therefore, tests of aspartame or methanol on animals do not accurately reflect the danger for humans.
“There are no human or mammalian studies to evaluate the possible mutagenic, teratogenic, or carcinogenic effects of chronic administration of methyl alcohol,” he said.
How can you know you are getting too much Methanol? You may experience headaches, ear buzzing, dizziness, nausea, gastrointestinal disturbances, weakness, vertigo, chills, memory lapses, numbness and shooting pains in the extremities, behavioral disturbances, and neuritis. Another very well known sign of methanol poisoning is vision problems.
Adding to the problem, one of the amino acids in aspartame, aspartic acid is capable of crossing your blood-brain barrier. There it attacks your brain cells, creating a form of cellular overstimulation called excitotoxicity, which can lead to cell death.
Your blood-brain barrier, which normally protects your brain from excess aspartate, as well as toxins, is not able to adequately protect you against the effects of aspartame consumption because it:
  • Is not fully developed during childhood
  • Does not fully protect all areas of the brain
  • Is damaged by numerous chronic and acute conditions
  • Allows seepage of excess aspartate into the brain even when intact
That excess aspartate slowly begins to destroy neurons, and the large majority (75 percent or more) of neural cells in a particular area of the brain are killed before any clinical symptoms of a chronic illness are noticed. Then, when they do occur, they may or may not be associated with aspartame consumption, even though examples of chronic illnesses that are made worse by long-term exposure to excitatory amino acid damage include: Multiple sclerosis (MS), ALS, hormonal problems, memory loss, epilepsy, hearing loss, Alzheimers, dementia, brain lesions, and Neuroendocrine disorders.
It can be easy for us to make the argument that this stuff is OK in small doses, and it hasn’t killed us yet so it can’t be that bad. But it almost seems there is something more to it why we use this reasoning. Are we just addicted to these substances? Afraid to admit we have been poisoning ourselves? Unable to accept that the FDA and health agencies have lied to us? Like to brush these truths off as conspiracies? No matter what the reason is, there comes a point where we must see what is staring us in the face and start looking at how we can begin making new choices. Returning to something that is healthier and more in line with our bodies. We are really damaging ourselves here and becoming quite numb to life. It is susbstances like Aspartame and Fluoride that are causing these issues and the difference it makes to avoid these substances is monumental for our quality of life and consciousness.
Update: One thing I really wanted to add to this article is geared towards really looking at ourselves when it comes to not just aspartame but food, beverage, cosmetics, etc. We all at some point consumed or used products that are not all that great for our bodies. Most of the everyday products we use contain very toxic chemicals, it’s just that we spend a lot of time seeing ad’s about them, using them and looking at the nice labels that look all happy so we don’t realize how bad this stuff really is for us. You may want to check THIS ARTICLE out for more info. The question I want to raise here is, why is it that when information is presented about chemicals and toxic products do we get in a rage about the information and want to justify the continuation of its use in our bodies, on our bodies and on the planet? Even if something like Aspartame was only half as bad as it really is, why would we even want that? Why is the connection we have to our bodies so lost that we want to subject it to toxins, carcinogens, chemicals and other products that 1. are not remotely natural and 2. are not something that should be near our bodies to begin with. It just seems as though the bigger issue here is that we have become very disconnected from not only our bodies but the planet as well. It has become about convenience, money, temporary happiness, filling emotional voids and staying stagnant. When this info is presented all of those buttons get pushed at once and next thing we know we are defending the use of something that should have never been brought into existence in the first place. To look at it further, even the amount of sugar and type of sugar we use in the products we use aspartame in as an alternative, is terrible as well. Any product that currently contains aspartame shouldn’t be consumed by humans to begin with. What is wrong with fruit? Vegetables? Nuts? Seeds? Why do we always need these artificially flavored and chemically enhanced products that are terrible for our health? Aspartame or no aspartame, the real thing to observe here is our disconnection from our bodies, life and the planet.
Sources: http://www.uabmedicine.org/news/Food+%28sugar+substitutes%29
http://www.mpwhi.com/aspartame_methanol_and_public_health.pdf
http://www.ncbi.nlm.nih.gov/pubmed/22385158